Historically, platinum has played a prominent role in organometallic chemistry. The compounds KPtCI,(C,H,)H,O (I), PtMe, (X) (2) and Chugaev's salt [PtC,H,,N,],Clx (3, 4) present some of the fist examples of stable metal-olefin, metal-alkyl and metalcarbene complexes, although ironically the nature of the bonding in these compounds was not immediately recognised. In the study of organometallic ...

Platinum-metal oxidation catalysts are to be introduced in exhaust systems of many 1975 model-year automobiles in the U.S. to meet Clean Air Act standards. Small quantities of finely divided catalyst have been found issuing from prototype systems; platinum and palladium compounds may be found also. Although platinum exhibits a remarkable resistance to oxidation and chemical attack, it reacts ch...

Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly of displaying anti-cancer and oncogenic properties simultaneously. Some antim...

Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic activity. By crystallographic analysis of transition metal-and in particular platinum compound-DNA site selectivity in the nucleosome core, we es...

The syntheses of nickel(II)porphyrins bearing palladium(II) or platinum(II) complexes at their periphery were performed. These new compounds characterized by standard spectroscopic techniques and studied electrochemistry. electrochemical data then compared with previously published porphyrin dimers linked metal ions like platinum(II). An X-ray structure one these species was obtained confirmed ...

In the past, metal-based compounds were widely used in the treatment of disease conditions, but the lack of clear distinction between the therapeutic and toxic doses was a major challenge. With the discovery of cisplatin by Barnett Rosenberg in 1960, a milestone in the history of metal-based compounds used in the treatment of cancers was witnessed. This forms the foundation for the modern era o...

A new ruthenium(ii) polypyridyl-platinum(ii) diethynyl triad containing 3-ethynylphenanthroline linked by platinum(ii) bis-tributylphosphine organometallics, Ru(ii)-Pt(ii)-Ru(ii), and platinum(ii) bis-ethynylphenanthroline complex has been prepared. The ruthenium(ii)-metal triads, Ru(ii)-M-Ru(ii) (M = Pt(ii) and Au(i)), showed typical MLCT absorption bands and a lowest energy pi-pi* absorption ...

From the metal ions and metal compounds that are known to bind to DNA, many anticancer Pt(II) and Ru(II)Ru(III) compounds are known to have ligand-exchange kinetics in the same order of magnitude as the division of tumor cells. The present article discusses this process in detail with special attention to cisplatin and related compounds and the cellular binding sites and processes of such compo...

Two organometallic compounds containing zinc and manganese in different ratios are used as single-source precursors for the preparation of various new, bimetallic oxide materials with nanoscaled dimensions. It is shown that the materials synthesis can be performed in the solid-state, the liquid-phase, and even in the gas-phase. The molecular composition of the precursors determines the composit...